CATH Classification

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

Q07820
MCL1_HUMAN
Homo sapiens
Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB 4ZBF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., Rossanese, O.W., Lee, T., Olejniczak, E.T., Fesik, S.W.
J.Med.Chem.
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