CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.200 | Phosphorylase Kinase; domain 1 | |
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Putative Serine/threonine-protein kinase/endoribonuclease IRE1 |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O75460
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
3.1.26.- |
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt O75460
|
UniProtKB Entries (1)
O75460 |
ERN1_HUMAN
Homo sapiens
Serine/threonine-protein kinase/endoribonuclease IRE1
|
PDB Structure
PDB | 4Z7H |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
Oncotarget
|