CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt O14686
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

O14686
KMT2D_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase 2D

PDB Structure

PDB 4Z4P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evolving Catalytic Properties of the MLL Family SET Domain.
Zhang, Y., Mittal, A., Reid, J., Reich, S., Gamblin, S.J., Wilson, J.R.
Structure