CATH Domain 4z2iA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family

Enzyme Information

3.2.1.14

Chitinase.

based on mapping to UniProt P11797

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.

-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P11797

CHIB_SERMA

Serratia marcescens

Chitinase B

PDB Structure

PDB	4Z2I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase Sugawara, A., Maita, N., Gouda, H., Yamamoto, T., Hirose, T., Kimura, S., Saito, Y., Nakano, H., Kasai, T., Nakano, H., Shiomi, K., Hirono, S., Watanabe, T., Taniguchi, H., Omura, S., Sunazuka, T. J.Med.Chem.