CATH Domain 4z22A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Plasmepsin-2

Enzyme Information

3.4.23.39

Plasmepsin II.

based on mapping to UniProt P46925

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.

-!- Inhibited by pepstatin. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P46925

PLM2_PLAFA

Plasmodium falciparum

Plasmepsin-2

PDB Structure

PDB	4Z22
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. Rasina, D., Otikovs, M., Leitans, J., Recacha, R., Borysov, O.V., Kanepe-Lapsa, I., Domraceva, I., Pantelejevs, T., Tars, K., Blackman, M.J., Jaudzems, K., Jirgensons, A. J.Med.Chem.