CATH Domain 4z1jA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.200	Carbonic Anhydrase II
	3.10.200.10	Alpha carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Alpha carbonic anhydrase
Functional Family	Carbonic anhydrase 2

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt P00918

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918

CAH2_HUMAN

Homo sapiens

Carbonic anhydrase 2

PDB Structure

PDB	4Z1J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Buemi, M.R., De Luca, L., Ferro, S., Bruno, E., Ceruso, M., Supuran, C.T., Pospisilova, K., Brynda, J., Rezacova, P., Gitto, R. Eur.J.Med.Chem.