CATH Domain 4yz9A03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1440	de novo design (two linked rop proteins)
	1.20.1440.180	KEN domain

Domain Context

CATH Clusters

Superfamily	KEN domain
Functional Family	Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt O75460 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-	Endoribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt O75460

UniProtKB Entries (1)

ERN1_HUMAN

Homo sapiens

Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB	4YZ9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 alpha Endoribonuclease Activity. Concha, N.O., Smallwood, A., Bonnette, W., Totoritis, R., Zhang, G., Federowicz, K., Yang, J., Qi, H., Chen, S., Campobasso, N., Choudhry, A.E., Shuster, L.E., Evans, K.A., Ralph, J., Sweitzer, S., Heerding, D.A., Buser, C.A., Su, D.S., DeYoung, M.P. Mol.Pharmacol.