CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.20 | 5' to 3' exonuclease, C-terminal subdomain |
Domain Context
CATH Clusters
| Superfamily | 5' to 3' exonuclease, C-terminal subdomain |
| Functional Family | DNA integrity scanning protein DisA |
Enzyme Information
| 2.7.7.85 |
Diadenylate cyclase.
based on mapping to UniProt Q9WY43
2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.
-!- Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule. -!- The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.
|
UniProtKB Entries (1)
| Q9WY43 |
DISA_THEMA
Thermotoga maritima MSB8
DNA integrity scanning protein DisA
|
PDB Structure
| PDB | 4YXJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J.
|
