CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.630 | Aminopeptidase |
|
3.40.630.10 | Zn peptidases |
Domain Context
CATH Clusters
| Superfamily | Zn peptidases |
| Functional Family | Glutaminyl-peptide cyclotransferase |
Enzyme Information
| 2.3.2.5 |
Glutaminyl-peptide cyclotransferase.
based on mapping to UniProt Q16769
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
-!- Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. -!- The enzyme from papaya also acts on glutaminyl-tRNA.
|
UniProtKB Entries (1)
| Q16769 |
QPCT_HUMAN
Homo sapiens
Glutaminyl-peptide cyclotransferase
|
PDB Structure
| PDB | 4YWY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.
Acta Crystallogr.,Sect.F
|
