CATH Classification

Domain Context

CATH Clusters

Superfamily Cupredoxins - blue copper proteins
Functional Family

Enzyme Information

1.7.2.1
Nitrite reductase (NO-forming).
based on mapping to UniProt P38501
Nitric oxide + H(2)O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H(+).
-!- The reaction is catalyzed by two types of enzymes, found in the perimplasm of denitrifying bacteria. -!- One type comprises proteins containing multiple copper centers, the other a heme protein, cytochrome cd1. -!- Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin. -!- Cytochrome cd1 also has oxidase and hydroxylamine reductase activities. -!- May also catalyze the reaction of EC 1.7.99.1 since this is a well- known activity of cytochrome cd1. -!- Formerly EC 1.6.6.5, EC 1.7.99.3 and EC 1.9.3.2.

UniProtKB Entries (1)

P38501
NIR_ALCFA
Alcaligenes faecalis
Copper-containing nitrite reductase

PDB Structure

PDB 4YSE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography
Fukuda, Y., Tse, K.M., Nakane, T., Nakatsu, T., Suzuki, M., Sugahara, M., Inoue, S., Masuda, T., Yumoto, F., Matsugaki, N., Nango, E., Tono, K., Joti, Y., Kameshima, T., Song, C., Hatsui, T., Yabashi, M., Nureki, O., Murphy, M.E., Inoue, T., Iwata, S., Mizohata, E.
Proc.Natl.Acad.Sci.USA