CATH Domain 4yrsA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.930	BirA Bifunctional Protein; domain 2
	3.30.930.10	Bira Bifunctional Protein; Domain 2

Domain Context

CATH Clusters

Superfamily	Bira Bifunctional Protein; Domain 2
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q4DA54_TRYCC

Trypanosoma cruzi strain CL Brener

Histidyl-tRNA synthetase, putative

PDB Structure

PDB	4YRS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Koh, C.Y., Siddaramaiah, L.K., Ranade, R.M., Nguyen, J., Jian, T., Zhang, Z., Gillespie, J.R., Buckner, F.S., Verlinde, C.L., Fan, E., Hol, W.G. Acta Crystallogr. D Biol. Crystallogr.