CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.30 | Glutaredoxin |
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3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
Superfamily | Glutaredoxin |
Functional Family | Glutathione S-transferase omega-1 |
Enzyme Information
2.5.1.18 |
Glutathione transferase.
based on mapping to UniProt P78417
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
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1.20.4.2 |
Methylarsonate reductase.
based on mapping to UniProt P78417
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
-!- The product, methylarsonite, is biologically methylated by EC 2.1.1.137 to form cacodylic acid. -!- Formerly EC 1.97.1.7.
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1.8.5.1 |
Glutathione dehydrogenase (ascorbate).
based on mapping to UniProt P78417
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
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UniProtKB Entries (1)
P78417 |
GSTO1_HUMAN
Homo sapiens
Glutathione S-transferase omega-1
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PDB Structure
PDB | 4YQV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.
Nat Commun
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