CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1270 | Trp Operon Repressor; Chain A |
|
1.10.1270.20 | tRNA(m1g37)methyltransferase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | tRNA(m1g37)methyltransferase, domain 2 |
| Functional Family | tRNA (guanine-N(1)-)-methyltransferase |
Enzyme Information
| 2.1.1.228 |
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt P43912
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.
|
UniProtKB Entries (1)
| P43912 |
TRMD_HAEIN
Haemophilus influenzae Rd KW20
TRNA (guanine-N(1)-)-methyltransferase
|
PDB Structure
| PDB | 4YPY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
To Be Published
|
