CATH Domain 4yndA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.10	Tetratricopeptide repeat domain

Domain Context

CATH Clusters

Superfamily	Tetratricopeptide repeat domain
Functional Family	N-lysine methyltransferase SMYD2 isoform X2

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9NRG4
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9NRG4 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SMYD2_HUMAN

Homo sapiens

N-lysine methyltransferase SMYD2

PDB Structure

PDB	4YND
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. Sweis, R.F., Wang, Z., Algire, M., Arrowsmith, C.H., Brown, P.J., Chiang, G.G., Guo, J., Jakob, C.G., Kennedy, S., Li, F., Maag, D., Shaw, B., Soni, N.B., Vedadi, M., Pappano, W.N. Acs Med.Chem.Lett.