CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.550 | Membrane associated eicosanoid/glutathione metabolism-like domain |
Domain Context
CATH Clusters
| Superfamily | Membrane associated eicosanoid/glutathione metabolism-like domain |
| Functional Family | Microsomal glutathione S-transferase 1 |
Enzyme Information
| 5.3.99.3 |
Prostaglandin-E synthase.
based on mapping to UniProt O14684
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.
|
UniProtKB Entries (1)
| O14684 |
PTGES_HUMAN
Homo sapiens
Prostaglandin E synthase
|
PDB Structure
| PDB | 4YK5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem.
|