CATH Domain 4y8cA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase 9A

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76083

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

PDE9A_HUMAN

Homo sapiens

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB	4Y8C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Huang, M., Shao, Y., Hou, J., Cui, W., Liang, B., Huang, Y., Li, Z., Wu, Y., Zhu, X., Liu, P., Wan, Y., Ke, H., Luo, H.B. Mol.Pharmacol.