CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.20 | Up-down Bundle |
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1.20.990 | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
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1.20.990.10 | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
Domain Context
CATH Clusters
Superfamily | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
Functional Family | NADPH--cytochrome P450 reductase |
Enzyme Information
1.6.2.4 |
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
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UniProtKB Entries (1)
P00388 |
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase
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PDB Structure
PDB | 4Y7C |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem.
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