CATH Classification

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family NAD-dependent deacetylase sirtuin-2

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q8IXJ6

UniProtKB Entries (1)

Q8IXJ6
SIR2_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-2

PDB Structure

PDB 4Y6O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Feldman, J.L., Dittenhafer-Reed, K.E., Kudo, N., Thelen, J.N., Ito, A., Yoshida, M., Denu, J.M.
Biochemistry