CATH Classification

Domain Context

CATH Clusters

Superfamily Cupin
Functional Family Ribosomal oxygenase 1

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q9H6W3
1.14.11.27
[Histone H3]-dimetyl-L-lysine-36 demethylase.
based on mapping to UniProt Q9H6W3
[Protein]-N(6),N(6)-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O(2) = [protein]-L-lysine + 2 succinate + 2 formaldehyde + 2 CO(2).
-!- Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. -!- Lysine residues exist in three methylation states (mono-, di- and trimethylated). -!- The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. -!- It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.

UniProtKB Entries (1)

P62917
RL8_HUMAN
Homo sapiens
60S ribosomal protein L8

PDB Structure

PDB 4Y3O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.
Wang, C., Zhang, Q., Hang, T., Tao, Y., Ma, X., Wu, M., Zhang, X., Zang, J.
Acta Crystallogr.,Sect.D
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