CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.930 | Syk Kinase; Chain A, domain 2 | |
1.10.930.10 | Syk Kinase; Chain A, domain 2 |
Domain Context
CATH Clusters
Superfamily | Syk Kinase; Chain A, domain 2 |
Functional Family | Tyrosine-protein kinase |
Enzyme Information
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43403
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
P43403 |
ZAP70_HUMAN
Homo sapiens
Tyrosine-protein kinase ZAP-70
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PDB Structure
PDB | 4XZ0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.
Biochem. J.
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