CATH Domain 4xycA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.20	Ubiquitin-like (UB roll)
	3.10.20.70	Glutamine synthetase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Glutamine synthetase, N-terminal domain
Functional Family	Glutamine synthetase

Enzyme Information

6.3.1.2

Glutamine synthetase.

based on mapping to UniProt P9WN38

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.

-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P9WN38

GLN1B_MYCTO

Mycobacterium tuberculosis CDC1551

Glutamine synthetase

PDB Structure

PDB	4XYC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies. Couturier, C., Silve, S., Morales, R., Pessegue, B., Llopart, S., Nair, A., Bauer, A., Scheiper, B., Poverlein, C., Ganzhorn, A., Lagrange, S., Bacque, E. Bioorg.Med.Chem.Lett.