CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Thymidylate kinase |
Enzyme Information
| 2.7.4.9 |
dTMP kinase.
based on mapping to UniProt A7WYM2
ATP + dTMP = ADP + dTDP.
|
UniProtKB Entries (1)
| A7WYM2 |
KTHY_STAA1
Staphylococcus aureus subsp. aureus Mu3
Thymidylate kinase
|
PDB Structure
| PDB | 4XWA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A highly potent antibacterial inhibitor of Gram-positive bacterial thymidylate kinase (TMK): SAR of piperidinyl thymines at position C5 and L1
Bioorg Med Chem Lett
|
