CATH Domain 4xuxA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Beta-lactamase

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P05364

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P05364

AMPC_ENTCL

Enterobacter cloacae

Beta-lactamase

PDB Structure

PDB	4XUX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. Hecker, S.J., Reddy, K.R., Totrov, M., Hirst, G.C., Lomovskaya, O., Griffith, D.C., King, P., Tsivkovski, R., Sun, D., Sabet, M., Tarazi, Z., Clifton, M.C., Atkins, K., Raymond, A., Potts, K.T., Abendroth, J., Boyer, S.H., Loutit, J.S., Morgan, E.E., Durso, S., Dudley, M.N. J.Med.Chem.