1 keywords

CATH Domain 4xtwA02

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.30 Roll
Topology 2.30.30 SH3 type barrels.
Homologous Superfamily 2.30.30.100  

Domain Context

CATH Clusters

Superfamily 2.30.30.100
Functional Family Bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase

Enzyme Information

UniProtKB Entries (1)

I6YFP0
I6YFP0_MYCTU
Mycobacterium tuberculosis H37Rv
Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase)

PDB Structure

PDB 4XTW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
Bockman, M.R., Kalinda, A.S., Petrelli, R., De la Mora-Rey, T., Tiwari, D., Liu, F., Dawadi, S., Nandakumar, M., Rhee, K.Y., Schnappinger, D., Finzel, B.C., Aldrich, C.C.
J.Med.Chem.