CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.3.1.20 |
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt P52895
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
|
| 1.1.1.357 |
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P52895
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
|
| 1.-.-.- |
Oxidoreductases.
based on mapping to UniProt P52895
|
UniProtKB Entries (1)
| P52895 |
AK1C2_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C2
|
PDB Structure
| PDB | 4XO6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.
Biochem.J.
|
