CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.200 | Phosphorylase Kinase; domain 1 |
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3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Mitogen-activated protein kinase 1 |
Enzyme Information
2.7.11.24 |
Mitogen-activated protein kinase.
based on mapping to UniProt P63086
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.
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UniProtKB Entries (1)
P63086 |
MK01_RAT
Rattus norvegicus
Mitogen-activated protein kinase 1
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PDB Structure
PDB | 4XNE |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D
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