CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.170 | Beta Complex |
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2.170.120 | RNA Polymerase Alpha Subunit; Chain A, domain 2 |
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2.170.120.12 | DNA-directed RNA polymerase, insert domain |
Domain Context
CATH Clusters
Superfamily | DNA-directed RNA polymerase, insert domain |
Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt Q9KWU8
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
Q9EZJ8 |
SIGA_THEAQ
Thermus aquaticus
RNA polymerase sigma factor SigA
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PDB Structure
PDB | 4XLP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife
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