CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.20 | Up-down Bundle |
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1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
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1.20.120.330 | Nucleotidyltransferases domain 2 |
Domain Context
CATH Clusters
Superfamily | Nucleotidyltransferases domain 2 |
Functional Family | protein-tyrosine kinase 2-beta isoform X1 |
Enzyme Information
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q14289
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
O60711 |
LPXN_HUMAN
Homo sapiens
Leupaxin
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PDB Structure
PDB | 4XEF |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry
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