CATH Domain 4xe0A04

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1010	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
	3.30.1010.10	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta

2.7.1.153

Phosphatidylinositol-4,5-bisphosphate 3-kinase.

based on mapping to UniProt O35904

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

PK3CD_MOUSE

Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB	4XE0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase delta. Somoza, J.R., Koditek, D., Villasenor, A.G., Novikov, N., Wong, M.H., Liclican, A., Xing, W., Lagpacan, L., Wang, R., Schultz, B.E., Papalia, G.A., Samuel, D., Lad, L., McGrath, M.E. J.Biol.Chem.