CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.75 | 5-stranded Propeller |
|
3.75.10 | L-arginine/glycine Amidinotransferase; Chain A |
|
3.75.10.10 | L-arginine/glycine Amidinotransferase; Chain A |
Domain Context
CATH Clusters
| Superfamily | L-arginine/glycine Amidinotransferase; Chain A |
| Functional Family | Protein-arginine deiminase type-2 |
Enzyme Information
| 3.5.3.15 |
Protein-arginine deiminase.
based on mapping to UniProt Q9UM07
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
-!- Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.
|
UniProtKB Entries (1)
| Q9UM07 |
PADI4_HUMAN
Homo sapiens
Protein-arginine deiminase type-4
|
PDB Structure
| PDB | 4X8G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat.Chem.Biol.
|
