CATH Domain 4x8cA01

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1860	Protein-arginine deiminase, N-terminal domain

Superfamily	Protein-arginine deiminase, N-terminal domain
Functional Family	Protein-arginine deiminase type-4

3.5.3.15

Protein-arginine deiminase.

based on mapping to UniProt Q9UM07

Protein L-arginine + H(2)O = protein L-citrulline + NH(3).

-!- Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.

PADI4_HUMAN

Homo sapiens

Protein-arginine deiminase type-4

PDB	4X8C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Lewis, H.D., Liddle, J., Coote, J.E., Atkinson, S.J., Barker, M.D., Bax, B.D., Bicker, K.L., Bingham, R.P., Campbell, M., Chen, Y.H., Chung, C.W., Craggs, P.D., Davis, R.P., Eberhard, D., Joberty, G., Lind, K.E., Locke, K., Maller, C., Martinod, K., Patten, C., Polyakova, O., Rise, C.E., Rudiger, M., Sheppard, R.J., Slade, D.J., Thomas, P., Thorpe, J., Yao, G., Drewes, G., Wagner, D.D., Thompson, P.R., Prinjha, R.K., Wilson, D.M. Nat.Chem.Biol.