CATH Domain 4x48B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.10	Periplasmic binding protein-like II

Domain Context

CATH Clusters

Superfamily	Periplasmic binding protein-like II
Functional Family	Glutamate receptor ionotropic, kainate 2

Enzyme Information

UniProtKB Entries (1)

GRIA2_RAT

Rattus norvegicus

Glutamate receptor 2

PDB Structure

PDB	4X48
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242). Shaffer, C.L., Patel, N.C., Schwarz, J., Scialis, R.J., Wei, Y., Hou, X.J., Xie, L., Karki, K., Bryce, D.K., Osgood, S.M., Hoffmann, W.E., Lazzaro, J.T., Chang, C., McGinnis, D.F., Lotarski, S.M., Liu, J., Obach, R.S., Weber, M.L., Chen, L., Zasadny, K.R., Seymour, P.A., Schmidt, C.J., Hajos, M., Hurst, R.S., Pandit, J., O'Donnell, C.J. J.Med.Chem.