CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.10 | Arc Repressor Mutant, subunit A | |
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Functional Family | Methylated-DNA--protein-cysteine methyltransferase |
Enzyme Information
2.1.1.63 |
Methylated-DNA--[protein]-cysteine S-methyltransferase.
based on mapping to UniProt P9WJW5
(1) DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. (2) DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine.
-!- This protein is involved in the repair of methylated DNA. -!- Unlike EC 3.2.2.20 and EC 3.2.2.21, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide. -!- Since the methyl transfer is irreversible, the enzyme can only catalyze a single turnover.
|
UniProtKB Entries (1)
P9WJW5 |
OGT_MYCTU
Mycobacterium tuberculosis H37Rv
Methylated-DNA--protein-cysteine methyltransferase
|
PDB Structure
PDB | 4WXC |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J.
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