CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.160 | Double Stranded RNA Binding Domain |
|
3.30.160.70 | Methylated DNA-protein cysteine methyltransferase domain |
Domain Context
CATH Clusters
| Superfamily | Methylated DNA-protein cysteine methyltransferase domain |
| Functional Family |
Enzyme Information
| 2.1.1.63 |
Methylated-DNA--[protein]-cysteine S-methyltransferase.
based on mapping to UniProt P9WJW5
(1) DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. (2) DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine.
-!- This protein is involved in the repair of methylated DNA. -!- Unlike EC 3.2.2.20 and EC 3.2.2.21, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide. -!- Since the methyl transfer is irreversible, the enzyme can only catalyze a single turnover.
|
UniProtKB Entries (1)
| P9WJW5 |
OGT_MYCTU
Mycobacterium tuberculosis H37Rv
Methylated-DNA--protein-cysteine methyltransferase
|
PDB Structure
| PDB | 4WX9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA.
Biochem.J.
|
