CATH Domain 4wvlA02

Superfamily	Vaccinia Virus protein VP39
Functional Family	Histone-lysine N-methyltransferase, H3 lysine-79 specific

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q8TEK3

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

DOT1L_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB	4WVL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement. Yi, J.S., Federation, A.J., Qi, J., Dhe-Paganon, S., Hadler, M., Xu, X., St Pierre, R., Varca, A.C., Wu, L., Marineau, J.J., Smith, W.B., Souza, A., Chory, E.J., Armstrong, S.A., Bradner, J.E. Acs Chem.Biol.