CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.460 | Beta Polymerase; domain 2 |
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3.30.460.40 |
Domain Context
CATH Clusters
Superfamily | 3.30.460.40 |
Functional Family |
Enzyme Information
2.7.7.46 |
Gentamicin 2''-nucleotidyltransferase.
based on mapping to UniProt P0AE05
Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin.
-!- ATP, dATP, CTP, ITP and GTP can act as donors. -!- Kanamycin, tobramycin and sisomicin can also act as acceptors. -!- The nucleotidyl residue is transferred to the 2-hydroxy group of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
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UniProtKB Entries (1)
P0AE05 |
AADB1_KLEPN
Klebsiella pneumoniae
2''-aminoglycoside nucleotidyltransferase
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PDB Structure
PDB | 4WQK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Mbio
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