CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.420 | Nucleotidyltransferase; domain 5 | |
3.30.420.40 | ATPase, nucleotide binding domain |
Domain Context
CATH Clusters
Superfamily | 3.30.420.40 |
Functional Family | tRNA N6-adenosine threonylcarbamoyltransferase |
Enzyme Information
2.3.1.234 |
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt P05852
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.
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UniProtKB Entries (1)
P05852 |
TSAD_ECOLI
Escherichia coli K-12
TRNA N6-adenosine threonylcarbamoyltransferase
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PDB Structure
PDB | 4WQ4 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli.
Nucleic Acids Res.
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