CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family B-Raf proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P15056
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056
BRAF_HUMAN
Homo sapiens
Serine/threonine-protein kinase B-raf

PDB Structure

PDB 4WO5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Thevakumaran, N., Lavoie, H., Critton, D.A., Tebben, A., Marinier, A., Sicheri, F., Therrien, M.
Nat.Struct.Mol.Biol.