CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family G protein-coupled receptor kinase

Enzyme Information

2.7.11.16
[G-protein-coupled receptor] kinase.
based on mapping to UniProt P43249
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
-!- All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. -!- (cf. EC 2.7.11.14 and EC 2.7.11.15).

UniProtKB Entries (1)

P43249
GRK5_BOVIN
Bos taurus
G protein-coupled receptor kinase 5

PDB Structure

PDB 4WNK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.
Homan, K.T., Waldschmidt, H.V., Glukhova, A., Cannavo, A., Song, J., Cheung, J.Y., Koch, W.J., Larsen, S.D., Tesmer, J.J.
J.Biol.Chem.
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