CATH Domain 4wnkA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.167	Regulator of G-protein Signalling 4; domain 2
	1.10.167.10	Regulator of G-protein Signalling 4, domain 2

Domain Context

CATH Clusters

Superfamily	Regulator of G-protein Signalling 4, domain 2
Functional Family	G protein-coupled receptor kinase

Enzyme Information

2.7.11.16

[G-protein-coupled receptor] kinase.

based on mapping to UniProt P43249

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

-!- All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. -!- (cf. EC 2.7.11.14 and EC 2.7.11.15).

UniProtKB Entries (1)

P43249

GRK5_BOVIN

Bos taurus

G protein-coupled receptor kinase 5

PDB Structure

PDB	4WNK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. Homan, K.T., Waldschmidt, H.V., Glukhova, A., Cannavo, A., Song, J., Cheung, J.Y., Koch, W.J., Larsen, S.D., Tesmer, J.J. J.Biol.Chem.