1 keywords

CATH Domain 4wleA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.37
Malate dehydrogenase.
based on mapping to UniProt P40926
(S)-malate + NAD(+) = oxaloacetate + NADH.
-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

P40926
MDHM_HUMAN
Homo sapiens
Malate dehydrogenase, mitochondrial

PDB Structure

PDB 4WLE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of citrate bound MDH2
Eo, Y.M., Han, B.G., Ahn, H.C.
To Be Published