CATH Domain 4wkeA00

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Superfamily	Collagenase (Catalytic Domain)
Functional Family	A disintegrin and metalloproteinase with thrombospondin motifs 1

3.4.24.82

ADAMTS-4 endopeptidase.

based on mapping to UniProt O75173

Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala- Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.

-!- Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix. -!- Belongs to peptidase family M12.

ATS4_HUMAN

Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 4

PDB	4WKE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis. Durham, T.B., Klimkowski, V.J., Rito, C.J., Marimuthu, J., Toth, J.L., Liu, C., Durbin, J.D., Stout, S.L., Adams, L., Swearingen, C., Lin, C., Chambers, M.G., Thirunavukkarasu, K., Wiley, M.R. J.Med.Chem.