CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-oxoacyl-[acyl-carrier-protein] reductase FabG

Enzyme Information

1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt Q9KQH7
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
-!- Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.

UniProtKB Entries (1)

Q9KQH7
FABG_VIBCH
Vibrio cholerae O1 biovar El Tor str. N16961
3-oxoacyl-[acyl-carrier-protein] reductase FabG

PDB Structure

PDB 4WJZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dissecting the Structural Elements for the Activation of beta-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.
Hou, J., Zheng, H., Chruszcz, M., Zimmerman, M.D., Shumilin, I.A., Osinski, T., Demas, M., Grimshaw, S., Minor, W.
J.Bacteriol.