CATH Domain 4wf6A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2030	Anthrax toxin lethal factor, domain 3, chain A
	1.10.2030.10	Anthrax toxin lethal factor, domain 3, chain A

Domain Context

CATH Clusters

Superfamily	Anthrax toxin lethal factor, domain 3, chain A
Functional Family

Enzyme Information

3.4.24.83

Anthrax lethal factor endopeptidase.

based on mapping to UniProt P15917

Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.

-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

P15917

LEF_BACAN

Bacillus anthracis

Lethal factor

PDB Structure

PDB	4WF6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. Kurbanov, E.K., Chiu, T.L., Solberg, J., Francis, S., Maize, K.M., Fernandez, J., Johnson, R.L., Hawkinson, J.E., Walters, M.A., Finzel, B.C., Amin, E.A. J.Med.Chem.