CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.930 | BirA Bifunctional Protein; domain 2 | |
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
Superfamily | Bira Bifunctional Protein; Domain 2 |
Functional Family | Bifunctional ligase/repressor BirA |
Enzyme Information
6.3.4.15 |
Biotin--[biotin carboxyl-carrier protein] ligase.
based on mapping to UniProt P06709
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
-!- The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14. -!- The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15. -!- In some organisms the carrier protein is part of EC 6.4.1.2.
|
UniProtKB Entries (1)
P06709 |
BIRA_ECOLI
Escherichia coli K-12
Bifunctional ligase/repressor BirA
|
PDB Structure
PDB | 4WF2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Allosteric Coupling via Distant Disorder-to-Order Transitions.
J.Mol.Biol.
|