CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.287 | Helix Hairpins |
|
1.10.287.110 | DnaJ domain |
Domain Context
CATH Clusters
| Superfamily | DnaJ domain |
| Functional Family |
Enzyme Information
| 2.7.11.11 |
cAMP-dependent protein kinase.
based on mapping to UniProt P17612
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| P25685 |
DNJB1_HUMAN
Homo sapiens
DnaJ homolog subfamily B member 1
|
PDB Structure
| PDB | 4WB7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into mis-regulation of protein kinase A in human tumors.
Proc.Natl.Acad.Sci.USA
|
