CATH Domain 4w8iA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

4.1.2.27

Sphinganine-1-phosphate aldolase.

based on mapping to UniProt Q5X3A8

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

UniProtKB Entries (1)

SGPL_LEGPA

Legionella pneumophila str. Paris

Probable sphingosine-1-phosphate lyase

PDB Structure

PDB	4W8I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy. Rolando, M., Escoll, P., Nora, T., Botti, J., Boitez, V., Bedia, C., Daniels, C., Abraham, G., Stogios, P.J., Skarina, T., Christophe, C., Dervins-Ravault, D., Cazalet, C., Hilbi, H., Rupasinghe, T.W., Tull, D., McConville, M.J., Ong, S.Y., Hartland, E.L., Codogno, P., Levade, T., Naderer, T., Savchenko, A., Buchrieser, C. Proc.Natl.Acad.Sci.USA