CATH Domain 4w7tA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	Heat shock protein HSP 90-alpha

Enzyme Information

UniProtKB Entries (1)

HS90A_HUMAN

Homo sapiens

Heat shock protein HSP 90-alpha

PDB Structure

PDB	4W7T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990. McBride, C.M., Levine, B., Xia, Y., Bellamacina, C., Machajewski, T., Gao, Z., Renhowe, P., Antonios-McCrea, W., Barsanti, P., Brinner, K., Costales, A., Doughan, B., Lin, X., Louie, A., McKenna, M., Mendenhall, K., Poon, D., Rico, A., Wang, M., Williams, T.E., Abrams, T., Fong, S., Hendrickson, T., Lei, D., Lin, J., Menezes, D., Pryer, N., Taverna, P., Xu, Y., Zhou, Y., Shafer, C.M. J.Med.Chem.