CATH Classification

Domain Context

CATH Clusters

Superfamily Protein N-terminal glutamine amidohydrolase, alpha beta roll
Functional Family Blast:Protein N-terminal glutamine amidohydrolase

Enzyme Information

3.5.1.122
Protein N-terminal glutamine amidohydrolase.
based on mapping to UniProt Q96HA8
N-terminal L-glutaminyl-[protein] + H(2)O = N-terminal L-glutamyl- [protein] + NH(3).
-!- This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. -!- Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate. -!- The latter serves as a substrate for EC 2.3.2.8 making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.

UniProtKB Entries (1)

Q96HA8
NTAQ1_HUMAN
Homo sapiens
Protein N-terminal glutamine amidohydrolase

PDB Structure

PDB 4W79
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.
Park, M.S., Bitto, E., Kim, K.R., Bingman, C.A., Miller, M.D., Kim, H.J., Han, B.W., Phillips, G.N.
Plos One
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