1 keywords

CATH Domain 4w63A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1820 alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Acetylcholinesterase

Enzyme Information

3.1.1.7
Acetylcholinesterase.
based on mapping to UniProt P04058
Acetylcholine + H(2)O = choline + acetate.
-!- Acts on a variety of acetic esters. -!- Also catalyzes transacetylations.

UniProtKB Entries (1)

P04058
ACES_TETCF
Tetronarce californica
Acetylcholinesterase

PDB Structure

PDB 4W63
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
Zha, X., Lamba, D., Zhang, L., Lou, Y., Xu, C., Kang, D., Chen, L., Xu, Y., Zhang, L., De Simone, A., Samez, S., Pesaresi, A., Stojan, J., Lopez, M.G., Egea, J., Andrisano, V., Bartolini, M.
J.Med.Chem.
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